2006 Biomarkers, Human Lupus Biology
The immune system’s T lymphocytes have the job of orchestrating a response to infected or malignant cells. In the case of autoimmune disease, the T lymphocytes generate a response to the body's own cells.
Dr. Liu has recently developed a unique test for people with lupus that measures the amount of complement proteins and antibodies on the surface of T lymphocytes that may be indicative of abnormal hyperactivity in these cells.
With her Novel Research Grant from the LRI, she is determining whether testing for this biomarker generates meaningful information for diagnosing lupus, monitoring disease activity, and understanding the origins and course of development of lupus in the immune system.
“I look forward to reading all the exciting developments at the LRI. I, like other LRI investigators, understand and truly appreciate LRI’s enormous contribution to the research of lupus and the support for lupus patients.” – Dr. Liu
A review chapter, titled “The Search for SLE Biomarkers,” slated for publication in Best Practice & Research Clinical Rheumatology in 2009.
In 2008, Dr. Liu won an NIH grant of $1.2 million to continue the research that she began with the LRI’s Novel Research Grant.