Results Are What Matter
In funding ideas that others wouldn’t risk—85 new ideas—the LRI has energized and advanced immune system research in lupus.
“The speed with which the Institute has changed the outlook for lupus research is remarkable.” – William E. Paul, MD, Chief, Laboratory of Immunology, NIAID-NIH, NIH Distinguished Investigator and chairman of the Lupus Research Institute’s scientific advisory board.
Key Lupus Research Institute Discoveries
- Genes that Increase Susceptibility to Lupus
We’ve identified two genes that make lupus-prone mice susceptible to lupus—fresh insight into how the disease develops. Scientists are now examining if the same genes are defective in people with lupus.
- How Lupus Damages Organs—Kidneys, Heart, Brain, Skin
We’ve confirmed five novel explanations for how lupus damages vital organs such as the kidneys, brain, and heart. Now there is real hope for strategies to stop the damage.
- Pathways that Enable Misguided Antibodies to Attack
We’ve discovered four pathways involved in auto-antibodies—to the body rather than outside invaders—that highlight possible ways to prevent lupus.
- Molecules that Determine Control of the Immune System
We’ve described four molecules that act as critical control points for the immune system. These molecules present drug targets for lupus and other autoimmune diseases.
- Targets for New Treatments
Promising results are enticing pharmaceutical companies to explore new drugs for lupus for the first time in decades.
- 20+ New Biomarkers for Diagnosing, Monitoring & Treating Lupus
Biomarkers are crucial for monitoring, managing, and determining treatment efficacy in lupus.
Six of the more than 20 identified by LRI investigators are being tested in human tissue and people with lupus.
Findings are widely published in the best journals, including Arthritis & Rheumatism, Nature, The Journal of Rheumatology, and Science.
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- B Cells
- Cardiovascular System
- Cell Signaling
- Central Nervous System
- Dendritic Cells
- Environmental Triggers
- Gender Matters
- General Immune System Function
- Human Lupus Biology
- Lupus Pregnancy
- New to Lupus
- New Treatments
- T Cells
- Target Identification
- Why the Lupus Immune System Reacts to Its Own DNA