LRI doesn’t dictate a path of research to follow.

Instead, it stays open to innovation and the best new ideas, and lets the science lead the way....

“Discovery has to be imagined, not managed.”

– Mark J. Shlomchik, MD, PhD
Professor of Laboratory Medicine and Immunology
Yale University School of Medicine

LRI scientists are asking: what makes lupus happen, and what can prevent or stop it?

Are the genes we inherit from our parents involved somehow?

Do errors or flaws in specific pathways or molecules in the body play a role—B cells, dendritic cells, signaling issues?

Or are problems in general immune system function to blame?

Why, for example, does the lupus immune system react to the body’s own DNA?

Could it be that environmental triggers jumpstart or exacerbate lupus?

Once lupus starts, what can be done about the attack on the central nervous system, the cardiovascular system, the kidneys, the skin, and other vital organs and precious tissues?

Why does gender—male or female—appears to matter in the risk and severity of lupus. Why?

What about the potential of biomarkers—early predictors—to take the guesswork out of diagnosing and treating lupus?

Are new treatments around the corner?