Kidney

LRI researchers are on the hunt for answers for the approximately 33 percent of people with lupus whose kidneys are attacked in lupus.

“The state of the art now is unfortunately a catch-up game. We start treating someone after they have the disease, but if we can diagnose it earlier, we can test therapeutic modalities that are less toxic and more likely to have an effect earlier in the disease process.”

– Elahna Paul, MD, PhD, Massachusetts General Hospital

Biomarkers (early markers) of kidney involvement
Three LRI researchers are looking at biomarkers that might signal the development or worsening of kidney disease through a simple blood or urine test—rather than grueling and often hazardous kidney biopsies.

Anne Davidson, MD
Feinstein Medical Research Institute, Manhasset, NY
Class of 2003/2004

Robert Winchester, MD
Columbia University College of Physicians and Surgeons, New York, NY
Class of 2004

Diagnosis
"This project directly addresses the difficulties that I (and all nephrologists) face when trying to decide how much immunosuppression patients with kidney disease need. The funding will be invaluable in giving me the opportunity to bring together expertise from radiology, chemistry, and other specialties. I think it will really permit us to develop a new and powerful diagnostic tool for lupus kidney disease." – Joshua Thurman, MD

Joshua Thurman, MD
University of Colorado, Denver, CO
Class of 2009

How and Why Lupus Damages the Kidneys

Roberto Caricchio, MD
Temple University, Philadelphia, PA
Class of 2008

Neil S. Greenspan, MD, PhD
Case Western Reserve University, Cleveland, OH
Class of 2002

Chandra Mohan, MD, PhD
University of Texas Southwestern Medical Center, Dallas, TX
Class of 2001

Chaim Putterman, MD
Albert Einstein College of Medicine, Bronx, NY
Class of 2001

Umesh Deshmukh, PhD
University of Virginia, Charlottesville, VA
Class of 2003/2004

Marcus Clark, MD
University of Chicago, IL
Class of 2005

Peter Mundel, MD
Mount Sinai School of Medicine, New York, NY
Class of 2002

Anne Davidson, MD
Feinstein Medical Research Institute, Manhasset, NY
Class of 2009

Robert M. Clancy, PhD
New York University School of Medicine, New York, NY
Class of 2011

Janusz Kabarowski, PhD
The University of Alabama at Birmingham, AL
Class of 2012

Jane Salmon, MD
Hospital for Special Surgery, New York, NY
Class of 2013