Hormone Therapy Does Not Worsen Lupus But May Increase Thrombosis Risk

Women with systemic lupus erythematosus (SLE) are at increased risk for premature menopause, with its attendant risks of osteoporotic fracture, however, hormone therapy (HT) is a possible treatment. Jorge Sanchez-Guerrero, MD, MS, and colleagues have conducted a double-blind, randomized, clinical trial allaying concerns that HT might worsen SLE activity but reinforcing fears that HT might add to an already elevated risk of thrombosis in women with SLE. The study is reported in Arthritis & Rheumatism.

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