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B Cells

In lupus, the immune system makes tragic wrong turns, attacking the organs and tissues of the body that it is supposed to defend.

Why does this happen?

What can be done about it?

LRI researchers have bold and out-of-the-box ideas on this.

Jeffrey Rathmell, PhD
Duke University Medical Center, Durham, NC
Class of 2009

Marko A. Radic, PhD
University of Tennessee, Memphis, TN
Class of 2009

Changchun Xiao, PhD
Scripps Research Institute, La Jolla, CA
Class of 2009

Anne Davidson, MD
Feinstein Medical Research Institute, Manhasset, NY
Class of 2009

One possibility: B cells are to blame. These cells mature in the bone marrow and develop into cells that make antibodies when stimulated.

Jennifer Anolik, MD, PhD
University of Rochester, NY
Class of 2007

Loren Erickson, PhD
University of Virginia, VA
Class of 2007

Edmund J. Gosselin, PhD
Albany Medical College, Albany, NY
Class of 2001

Thereza Imanishi-Kari, PhD
Tufts University School of Medicine, Boston, MA
Class of 2006

Thomas Rothstein, MD, PhD
The Feinstein Institute for Medical Research, NY
Class of 2007

Martin Weigert, PhD
University of Chicago, IL
Class of 2001

Barbara J. Vilen, PhD
University of North Carolina at Chapel Hill, NC
Class of 2001

Hidde Ploegh, PhD
Whitehead Institute for Biomedical Research, Cambridge, MA
Class of 2008

Other possibilities being explored: the lupus immune system makes its tragic wrong turns because of